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University of Aberdeen and TauRx Therapeutics research:
New treatment halts progress of Alzheimer’s disease
A major breakthrough in the treatment of Alzheimer's disease was revealed by scientists at the Alzheimer's Association International Conference on Alzheimer's Disease [ICAD 2008] in Chicago, Illinois. Their pioneering research points to a new treatment that appears to slow the progress of the disorder, and could offer hope to millions worldwide. The product, remberTM, is the first drug to act on the tangles discovered by Alois Alzheimer over a century ago.
The research team at the University of Aberdeen, United Kingdom, working with TauRx Therapeutics, a Singapore–based company, developed a treatment which targets the tangles, aggregates of abnormal fibres of tau protein forming inside nerve cells in the brain. These aggregates first destroy nerve cells critical for memory and then destroy neurons in other parts of the brain as the disease progresses.
Patients taking part in the study treatment experienced a reduction in cognitive decline over one year, and did not experience a significant decline in their mental function over 19 months. The TauRx brain imaging data also showed that the drug had its biggest effect in the memory critical parts of the brain where the tangle density is highest.
Alzheimer's disease is a degenerative and terminal brain disorder which affects millions of people around the world and a major and growing burden on health services in all countries with an ageing population. During the course of its progress there is a build–up in the brain of lesions called plaques and tangles.
Following the results from the phase two clinical trial, a phase three trial could begin next year. If the phase three trial confirms the phase two findings, the drug could be available by 2012.
For more information visit the University's website at: www.abdn.ac.uk.
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